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  • Changelog
    v0.1 cell line networks
    v0.2 aggregate tissue networks
    v0.3 TF enrichement tool
    v0.4 single-sample tissue networks
    v0.5 CLUEreg tool
    v0.6 colon cancer networks
    v0.7 drug networks
    v0.7.1 API v1
    v0.8 liver, cervix, and breast cancer networks
    v0.9 miRNA tissue networks
    v0.9.1 bootstrap 5
    v1.0 glioblastoma networks
    v1.0.1 drug combinations
    v1.1 Cell line networks
    v1.2 User upload network
    v1.2.1 Gene targeting table
    v1.2.2 DRAGON miRNA network
    v1.3 Network comparison
    v1.3.1 Guided tours
    v1.4.0 CCLE multi-omic map
    v1.5.0 EGRET networks
    v1.6.0 BONOBO networks
    v1.7.0 tcga-data-nf networks

    Cell lines

    The cell line resource includes 1,376 sample-specific gene regulatory networks for TF regulation derived from CCLE data, 6 aggregate networks, and 359 genotype-specific networks in normal human cell lines modeling miRNA and TF regulation from GTEx data, and an aggregate miRNA network across all CCLE cell lines.

    Click on the bar plot to filter the table below.

    Bubble size reflects the number of regulators (TFs/miRNA) in the network. Click on the bubble plot to filter the table below.

    Number Tissue type Methods Regulator Condition Network types Datasets
    1 All DRAGON miRNA Cancer aggregate CCLE
    2 Fibroblast PANDA, PUMA TF, miRNA Normal (primary) aggregate GTEx
    3 LCL PANDA, PUMA, EGRET TF, miRNA Normal (transformed) aggregate GTEx
    4 Adrenal Cancer LIONESS TF Cancer single-sample CCLE
    5 Bile Duct Cancer LIONESS TF Cancer single-sample CCLE
    6 Bladder Cancer LIONESS TF Cancer single-sample CCLE
    7 Bone Cancer LIONESS TF Cancer single-sample CCLE
    8 Brain Cancer LIONESS TF Cancer single-sample CCLE
    9 Breast Cancer LIONESS TF Cancer single-sample CCLE
    10 Cervical Cancer LIONESS TF Cancer single-sample CCLE
    11 Colon/Colorectal Cancer LIONESS TF Cancer single-sample CCLE
    12 Embryonal Cancer LIONESS TF Cancer single-sample CCLE
    13 Endometrial/Uterine Cancer LIONESS TF Cancer single-sample CCLE
    14 Engineered LIONESS TF Cancer single-sample CCLE
    15 Esophageal Cancer LIONESS TF Cancer single-sample CCLE
    16 Eye Cancer LIONESS TF Cancer single-sample CCLE
    17 Fibroblast LIONESS TF Cancer single-sample CCLE
    18 Gallbladder Cancer LIONESS TF Cancer single-sample CCLE
    19 Gastric Cancer LIONESS TF Cancer single-sample CCLE
    20 Head and Neck Cancer LIONESS TF Cancer single-sample CCLE
    21 Kidney Cancer LIONESS TF Cancer single-sample CCLE
    22 Leukemia LIONESS TF Cancer single-sample CCLE
    23 Liposarcoma LIONESS TF Cancer single-sample CCLE
    24 Liver Cancer LIONESS TF Cancer single-sample CCLE
    25 Lung Cancer LIONESS TF Cancer single-sample CCLE
    26 Lymphoma LIONESS TF Cancer single-sample CCLE
    27 Myeloma LIONESS TF Cancer single-sample CCLE
    28 Neuroblastoma LIONESS TF Cancer single-sample CCLE
    29 Ovarian Cancer LIONESS TF Cancer single-sample CCLE
    30 Pancreatic Cancer LIONESS TF Cancer single-sample CCLE
    31 Prostate Cancer LIONESS TF Cancer single-sample CCLE
    32 Rhabdoid LIONESS TF Cancer single-sample CCLE
    33 Sarcoma LIONESS TF Cancer single-sample CCLE
    34 Skin Cancer LIONESS TF Cancer single-sample CCLE
    35 Teratoma LIONESS TF Cancer single-sample CCLE
    36 Thyroid Cancer LIONESS TF Cancer single-sample CCLE
    37 IPSC EGRET, PANDA TF Normal aggregate Banovich et al.
    38 IPSC-Cardiomyocyte EGRET, PANDA TF Normal aggregate Banovich et al.
    39 K562 EGRET TF Normal aggregate ENCODE
    40 GM12878 EGRET TF Normal aggregate ENCODE
    Contact

    Department of Biostatistics
    Harvard T.H. Chan School of Public Health

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