GRAND is a collection of gene regulatory networks derived from human tissues, cancer, cell lines, and small molecule drugs. These networks are bipartite graphs linking either transcription factors (TFs) or miRNAs to their target genes. GRAND includes an integrated webserver to test for enrichment of a list of TFs in a set of libraries as well as a tool (CLUEreg) to find compounds that reverse/exacerbate a gene or TF regulatory profile.

Drugs Small molecules

173,013 TF and gene targeting scores accounting for 2,858 drugs using data from CLUE and DRH.

Cancer Cancer

28 cancer-specific TF regulatory networks and 2,811 patient-specific networks using data from TCGA and GEO.

Tissues Tissues

36 tissue-specific TF and miRNA regulatory networks and 8,279 single-sample networks using data from GTEx.

Cell lines Cell lines

TF and miRNA regulatory networks for 1,378 normal and cancer cell lines across 37 tissues of origin using data from CCLE and GTEx.