GRAND is a collection of gene regulatory networks of human tissues, cancer, cell lines, and small molecule effects. The networks are bipartite graphs linking Transcription Factors (TFs) and miRNAs to their target genes. GRAND integrates a webserver to test the enrichment of a list of TFs in a set of libraries or find compounds that reverse/exacerbate a gene or TF regulatory profile. To date, we analyzed 452 gene sets.

Drugs Small molecules

173,013 TF and gene targeting profiles accounting for 2858 drugs computed from the CLUE gene expression collection and DRH database.

Cancer Cancer

2811 patient-specific regulatory networks across 28 cancer types using expression data from TCGA and GEO.

Tissues Tissues

36 tissue-specific TF and miRNA regulation and 8279 single-sample gene regulatory network using GTEx gene expression collection.

Cell lines Cell lines

Gene regulatory networks for 1378 normal and cancer cell lines from CCLE and GTEx covering TF and miRNA regulation.