Targeting refers to a bipartite network metric. For genes, targeting is the weighted indegree. For TFs, it represents the weighted outdegree.
The enrich function submits the selected TFs for enrichment analysis.
The CLUEreg function submits the selected TFs/Genes in CLUEreg, which finds optimal compounds that reverse the TF/Gene profile. High-targeted genes/TFs are those that have a positive z-score and low-targeted genes are those with negative z-score. CLUEreg requires both high-targeted and low-targeted genes/TFs to be nonempty sets.