GRAND

First upload the file in the first tab. Then, in the second tab, please click on the submit button after selecting the parameters to retrieve the network from the server.

Edge weights table

Source	Target	Edge weight

max. 500 megabytes

This tool allows users to upload their own network, visualize the network structure, and compute targeting scores for genes and TFs in the network. The network should be formatted as an adjacency matrix representing a set of regulators (TFs/miRNA) in the rows and a set of target genes in the columns, with regulator names as row names and gene names as columns names. See this example file for reference.

After uploading the network in the first tab (1. Upload network), you can visualize the network in the second tab (2. Visualize network) by clicking submit after selecting the parameters of interest. Or you can switch to the third tab (3. Compute targeting) to perform an exploratory analysis of the network including enrichment and drug repurposing analysis. Try the for a step-by-step explanation.

Gene Targeting score

Gene	Targeting score

TF Targeting score

Regulator	Targeting score

Edges

Node scaling

Node selection

Network view

Targeting view

Step 1:
Targeting scores

1. Genes

Gene selection

2. TFs

Step 2:
Analysis