To get the full list of phenotypic variables, please check the menu below. Please click on the scatter plot to access the network view page.

Tool description

PANDA reconstructs a gene regulatory network using TF PPI, TF DNA binding motif as regulation prior, and gene expression samples. PUMA reconstructs a gene regulatory network with miRNA as regulators using gene expression samples and miRNA predicted targets by miRanda or TargetScan as regulation priors. The Regulator-regulator interaction matrix is set to the identity matrix in the algorithm. LIONESS reconstructs patient-specific PANDA networks for each gene expression sample.

BONOBO is a single-sample network inference method, which can be used to estimate patient-specific co-expression matrices, which are then fed as input for PANDA to build patient-specific GRNs. To adapt BONOBO-PANDA networks for patient's sex, and in addition to sample-specific co-expression, PANDA's motif prior networks are constructed for each sex (accounting for sex chromosomes), while the third input (PPI networks) are generic for all patients. To download sample-specific networks, you can check the phenotypic information and select the networks by clinical variables or download all the samples in a single file.

Variable description

PANDA-LIONESS networks are single-sample networks generated by first estimating an aggregate PANDA network then deriving patient-specific LIONESS networks. You can either download all the networks to get a matrix of size the number of samples by the number of edges. The number of edges is 644 * 30243 (number of miRNA/TFs * number of genes) (~ 106). Otherwise, you can specify the sample network to download and you will get a miRNA/TF-by-gene matrix named after the GTEx sample reference.

SampleSubjectGender
AgeDTH-HRDY
SMAT-SSCR
SMRIN
SMTS
SMUBRID
Isch. time
Time point
Net.
All All - - - - - - - - -
Edg67 GB
GTEX-111CU-1426-SM-5GZYP GTEX-111CU 1 50-59 0 1 7.8 Colon 1157 100 Actual Death
Adj369 MBVis
GTEX-111VG-2226-SM-5N9DU GTEX-111VG 1 60-69 3 3 5.7 Colon 1157 1064 Actual Death
Adj369 MBVis
GTEX-111YS-1626-SM-5GZZ9 GTEX-111YS 1 60-69 0 1 7.8 Colon 1157 168 Actual Death
Adj369 MBVis
GTEX-1122O-1526-SM-5N9CL GTEX-1122O 2 60-69 0 1 7.8 Colon 1157 111 Actual Death
Adj369 MBVis
GTEX-1128S-1626-SM-5H12O GTEX-1128S 2 60-69 2 3 5.8 Colon 1157 865 Actual Death
Adj369 MBVis
GTEX-117YW-1826-SM-5PNY5 GTEX-117YW 1 50-59 3 2 6.2 Colon 1157 895 Actual Death
Adj369 MBVis
GTEX-117YX-0826-SM-5H11J GTEX-117YX 1 50-59 0 1 8.5 Colon 1157 92 Actual Death
Adj369 MBVis
GTEX-11DXX-1826-SM-5H126 GTEX-11DXX 2 60-69 0 1 7 Colon 1157 127 Actual Death
Adj369 MBVis
GTEX-11DXZ-1726-SM-5H12M GTEX-11DXZ 1 50-59 0 1 6.8 Colon 1157 307 Actual Death
Adj369 MBVis
Showing 1 to 10 of 204 entries